In Fallout 76, surviving the Wasteland’s many threats isn’t just about brute force. Utility items—whether they’re used for healing, defense, crafting, or exploration—can be the difference between a frustrating encounter and a smooth run. After hundreds of hours roaming Appalachia, I’ve compiled a list of 17 PvE must-haves that every player should keep on hand. These aren’t flashy or rare collectibles, but they’re incredibly useful, especially if you like to play smart and stay alive.

1. Stimpak (Super & Diluted)

It’s a no-brainer, but many still underestimate the need to stockpile Stimpaks. Super Stimpaks are a quick save in emergencies, while diluted ones are efficient for healing after minor skirmishes.

2. RadAway & Rad-X

Radiation management is critical in certain zones like the Cranberry Bog or Watoga. Keep a few RadAway and Rad-X in your inventory at all times, especially during PvE boss fights.

3. Repair Kits

Instead of running back to a workbench mid-fight, Repair Kits keep your gear in peak condition. They’re a solid pickup for PvE grinders, especially during events like Radiation Rumble.

4. Stealth Boys

Whether you’re sneaking into high-level zones or reviving teammates unnoticed, Stealth Boys offer tactical flexibility in PvE without investing in sneak-heavy builds.

5. Disease Cures

Diseases are annoying and persistent. A single tick bite or gulp from unpurified water can give you one. Always have at least 3 or 4 cures ready before entering swampy areas or irradiated zones.

6. Bobbleheads (Temporary Boosts)

They may not be permanent, but using the right Bobblehead before a fight—like Strength, Intelligence, or Endurance—can give you a noticeable edge.

7. Magazines

Temporary buffs from magazines like Tesla Science or Grognak the Barbarian can be a game-changer for PvE events. Stack them before engaging high-tier enemies.

8. C.A.M.P. Portable Kits

You never know when you’ll need to quickly set up a C.A.M.P. to repair, stash loot, or cook food. It’s also one of the smartest ways to reset a farming route.

9. Food Buffs (e.g., Grilled Radstag, Yao Guai Roast)

Food is often overlooked, but cooked meat provides vital stat boosts like carry weight and damage. Grilled Radstag is a favorite for explorers.

10. Purified Water

Beyond being essential for survival, purified water is also used in crafting and selling. It’s cheap to produce and easy to stock up. A favorite among players who like to buy Fallout 76 Caps cheap and flip items efficiently.

11. Serums (Marsupial, Speed Demon, etc.)

Certain mutation serums can completely change how you approach PvE. Marsupial’s jump boost and Speed Demon’s movement speed make them perfect for exploration-heavy builds.

12. Turret Plans & Turrets

Setting up auto-turrets during Scorched Earth or other high-stakes events can give you breathing room. Crafting these with cheap Fallout 76 Items can turn you into a portable defense hub.

13. Backpack Mods (Insulated, High Capacity)

If you're serious about PvE, your backpack should match your playstyle. High Capacity increases your carry weight, while Insulated protects against radiation-heavy environments.

14. Tinker’s Workbench

For players who roam often, having a portable Tinker’s Workbench at your C.A.M.P. makes crafting ammo or bulk items easier—especially when prepping for dailies.

15. Auto-Ax or Chainsaw Mods

Surprisingly strong in PvE, especially when modded correctly. You can craft or find these using cheap Fallout 76 Items through reliable trade sources like U4GM.

16. Fusion Cores (Charged)

Power Armor users should never go without a backup Fusion Core or two. PvE combat is energy-intensive, and nothing’s worse than being stranded mid-fight.

17. Grenades (Cryo, Plasma, Nuka)

Grenades are perfect for crowd control during public events. Whether freezing enemies or causing AoE damage, they’re affordable and always effective.

PvE in Fallout 76 isn’t just about DPS. It’s about utility, versatility, and planning. If you keep these 17 items in your stash or inventory, you’ll be ready for almost any encounter the game throws at you. Players looking to optimize faster sometimes prefer to buy Fallout 76 Caps cheap or snag cheap Fallout 76 Items from sources like U4GM, which helps you stay ahead without excessive grinding.

Stay prepared, stay smart, and enjoy the Wasteland.